特雷姆2
小胶质细胞
神经科学
疾病
陶氏病
阿尔茨海默病
β淀粉样蛋白
医学
先天免疫系统
生物
免疫学
神经退行性变
炎症
免疫系统
病理
作者
Jinchao Hou,Yun Chen,Gary E. Grajales‐Reyes,Marco Colonna
标识
DOI:10.1186/s13024-022-00588-y
摘要
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.
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