重新分配
病毒学
生物
H5N1亚型流感病毒
大流行
病毒
甲型流感病毒
病毒进化
基因组
基因
2019年冠状病毒病(COVID-19)
遗传学
医学
疾病
传染病(医学专业)
病理
作者
Fei Meng,Yan Chen,Zuchen Song,Qiu Zhong,Yijie Zhang,Chuanling Qiao,Yan Cheng,Huihui Kong,Liling Liu,Chengjun Li,Huanliang Yang,Hualan Chen
标识
DOI:10.1007/s11427-022-2208-0
摘要
Animal influenza viruses continue to pose a threat to human public health. The Eurasian avian-like H1N1 (EA H1N1) viruses are widespread in pigs throughout Europe and China and have caused human infections in several countries, indicating their pandemic potential. To carefully monitor the evolution of the EA H1N1 viruses in nature, we collected nasal swabs from 103,110 pigs in 22 provinces in China between October 2013 and December 2019, and isolated 855 EA H1N1 viruses. Genomic analysis of 319 representative viruses revealed that these EA H1N1 viruses formed eight different genotypes through reassortment with viruses of other lineages circulating in humans and pigs, and two of these genotypes (G4 and G5) were widely distributed in pigs. Animal studies indicated that some strains have become highly pathogenic in mice and highly transmissible in ferrets via respiratory droplets. Moreover, two-thirds of the EA H1N1 viruses reacted poorly with ferret serum antibodies induced by the currently used H1N1 human influenza vaccine, suggesting that existing immunity may not prevent the transmission of the EA H1N1 viruses in humans. Our study reveals the evolution and pandemic potential of EA H1N1 viruses and provides important insights for future pandemic preparedness.
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