Radiosynthesis of α-[18F]Fluoroamides with [18F]AgF

Abstract A silver-promoted nucleophilic radiofluorination of α-bromoamides has been developed for the radiosynthesis of α-[18F]fluoroamides. The reaction conditions are straightforward and compatible with primary, secondary, and tertiary α-bromoamides. Furthermore, the methodology has been successfully applied to the synthesis of bioactive radiotracers with good radiochemical conversion (RCC) and radiochemical yield (RCY).