痴呆
荟萃分析
糖尿病
危险系数
医学
认知
2型糖尿病
梅德林
随机对照试验
内科学
重症监护医学
生物信息学
内分泌学
精神科
置信区间
疾病
化学
生物
生物化学
作者
Y J Youn,Seung Yeon Kim,Hyun‐Jeong Jeong,Young‐Mi Ah,Yun Mi Yu
标识
DOI:10.1016/j.yfrne.2024.101131
摘要
This systematic review and meta-analysis aimed to determine the association between the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as cognitive function in patients with diabetes mellitus. We comprehensively searched the MEDLINE, Embase, and CENTRAL databases to select relevant studies published up to August 2023. The use of SGLT-2 inhibitors significantly lowers dementia risk compared to SGLT-2i non-users (Hazard ratio: 0.68, 95 % CI: 0.50–0.92). Furthermore, our findings indicated a positive effect of SGLT-2 inhibitor use on cognitive function score improvement, as demonstrated by the standardized mean difference of 0.88 (95 % CI: 0.32–1.44), particularly among populations with mild cognitive impairment or dementia. This systematic review and meta-analysis indicate a potential role of SGLT-2 inhibitors in reducing the risk of dementia in patients with diabetes mellitus. These findings underscore the need for well-controlled large clinical trials and future research in this field.
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