睾酮(贴片)
自噬
精子发生
粒体自噬
体内
细胞生物学
内科学
内分泌学
基因敲除
化学
生物
医学
细胞培养
细胞凋亡
生物化学
遗传学
作者
Lianlian Jiang,Xiaojun Lin,Jinchen Jiang,Chong Qiu,Shaokai Zheng,Nannan Zhao,Zhenhao Shu,Yan Qian,Lianglin Qiu
标识
DOI:10.1016/j.scitotenv.2024.170701
摘要
Epidemiological studies have found that long-term inhalation of PM2.5 is closely related to spermatogenesis disorders and infertility, but the underlying molecular mechanism is still unidentified. Testosterone, an essential reproductive hormone produced by Leydig cells, whose synthesis is disrupted by multiple environmental pollutants. In the current study, we explored the role of METTL3-m6A-SIRT1 axis-mediated abnormal autophagy in PM2.5-induced inhibition of testosterone production in in vivo and in vitro models. Our in vivo findings shown that long-term inhalation of PM
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