Synthesis of Natural Products and their Derivatives Using Dynamic Crystallization

Abstract Recent syntheses of natural products and their derivatives require compounds of ever-increasing complexity. Therefore, the control of selectivity becomes more challenging under conventional kinetic and thermodynamic conditions in solution. Dynamic crystallization (alternatively referred to as crystallization-induced transformation: CIT) has been recognized as a practical approach to control the selectivity when the desired product is the less-soluble crystal under equilibrium conditions. This highlight review summarizes the applications of dynamic crystallization to natural product synthesis.