脂肪肝
等位基因
肝细胞
医学
基因
疾病
生物
内科学
遗传学
体外
作者
Elisa Fabbrini,Brian Rady,Anastasiya Koshkina,Jae Yoon Jeon,Vivaswath S. Ayyar,Cynthia Gargano,Nicholas DiProspero,Susan Wendel,Julia Hegge,Holly Hamilton,Zhiming Ding,Maria Afrazi,Anthony L. Nicholas,Tao Pei,Masayoshi Nakano,Shohei Ouchi,Yuki Saito,Aimi Yamashita,Ryo Tamamura,Hernan Salazar
摘要
Homozygosity for the PNPLA3 risk allele is linked to liver fat accumulation. In phase 1 trials, JNJ-75220795, a hepatocyte-targeted GalNAc-conjugated PNPLA3 siRNA, reduced liver fat in PNPLA3 I148M homozygous patients with metabolic dysfunction–associated fatty liver disease.
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