Wnt信号通路
胶质瘤
生物
小RNA
信号转导
癌症研究
机制(生物学)
HMGA2型
环状RNA
神经科学
计算生物学
生物信息学
细胞生物学
遗传学
基因
哲学
认识论
作者
Neda Hedayati,Alireza Mafi,Azam Shirinabadi Farahani,Mehrdad Hashemi,Noushin Nabavi,Mina Alimohammadi,Payman Rahimzadeh,Afshin Taheriazam,Najmeh Farahani
标识
DOI:10.1016/j.prp.2024.155510
摘要
Gliomas are among the most common cancers in the central nervous system, arising through various signaling pathways. One significant pathway is Wnt signaling, a tightly regulated process that plays a crucial role in gliomagenesis and development. The current study aims to explore the relationship between circular RNAs (circRNAs) and the Wnt/β-catenin signaling pathway in gliomas, considering the growing recognition of circRNAs in disease pathogenesis. A comprehensive review of recent research was conducted to investigate the roles of circRNAs in gliomas, focusing on their expression patterns and interactions with the Wnt signaling pathway. The analysis included studies examining circRNAs' function as microRNA sponges and their impact on glioma biology. The findings reveal that circRNAs are differentially expressed in gliomas and significantly influence the occurrence, growth, and metastasis of these tumors. Specifically, circRNAs interact with the Wnt signaling pathway, affecting glioma development and progression. This interaction highlights the importance of circRNAs in glioma pathophysiology. Understanding the regulatory network involving circRNAs and Wnt signaling offers valuable insights into glioma pathophysiology. CircRNAs hold promise as diagnostic and prognostic biomarkers and may serve as targets for novel therapeutic strategies in glioma treatment.
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