溶酶体
自噬
细胞生物学
胞吐
自噬体
细胞外
生物
分泌物
生物化学
细胞凋亡
酶
作者
Takami Sho,Ying Li,Haifeng Jiao,Li Yu
标识
DOI:10.1083/jcb.202403195
摘要
Lysosomes, essential for intracellular degradation and recycling, employ damage-control strategies such as lysophagy and membrane repair mechanisms to maintain functionality and cellular homeostasis. Our study unveils migratory autolysosome disposal (MAD), a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring autophagy machinery, SNARE proteins, and cell migration. This mechanism, crucial for mitigating lysosomal damage, underscores the role of cell migration in lysosome damage control and facilitates the release of small extracellular vesicles, highlighting the intricate relationship between cell migration, organelle quality control, and extracellular vesicle release.
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