Investigation of Human Aging at the Single-Cell Level

生物 神经科学
作者
Yunjin Li,Qixia Wang,Yuan Xuan,Jian Zhao,Li Jin,Yuncai Tian,Geng Chen,Fei Tan
出处
期刊:Ageing Research Reviews [Elsevier]
卷期号:: 102530-102530
标识
DOI:10.1016/j.arr.2024.102530
摘要

Human aging is characterized by a gradual decline in physiological functions and an increased susceptibility to various diseases. The complex mechanisms underlying human aging are still not fully elucidated. Single-cell sequencing (SCS) technologies have revolutionized aging research by providing unprecedented resolution and detailed insights into cellular diversity and dynamics. In this review, we discuss the application of various SCS technologies in human aging research, encompassing single-cell, genomics, transcriptomics, epigenomics, and proteomics. We also discuss the combination of multiple omics layers within single cells and the integration of SCS technologies with advanced methodologies like spatial transcriptomics and mass spectrometry. These approaches have been essential in identifying aging biomarkers, elucidating signaling pathways associated with aging, discovering novel aging cell subpopulations, uncovering tissue-specific aging characteristics, and investigating aging-related diseases. Furthermore, we provide an overview of aging-related databases that offer valuable resources for enhancing our understanding of the human aging process.
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