干扰素
癌症研究
癌症
肝癌
生物
医学
化学
免疫学
遗传学
肝细胞癌
作者
Zhaofeng Xiao,Huan Chen,Nan Xu,Yiyuan Chen,Shuai Wang,Xiao Xu
标识
DOI:10.1016/j.canlet.2024.217231
摘要
MATR3 is a nuclear matrix protein implicated in various cancers; however, its specific role in tumor progression remains unclear. The study utilized the TCGA database to reveal that MATR3 expression is upregulated in liver cancer and is correlated with poor prognosis. Functionally, MATR3 promoted liver cancer cell proliferation and metastasis. Comprehensive RNA sequencing analysis showed that MATR3 significantly affected the type I IFN signaling pathway and DHX58 is a downstream target of MATR3. Further experiments showed that MATR3 bound to DHX58 mRNA through its RRM structural domain and recruited YTHDF2, an m
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