The modulation of Airy vortex beam by electromagnetically induced transparency (EIT) effect and Kerr nonlinear effect is studied theoretically and experimentally. We introduce the vortex to Airy beam through the interference between the lobes of Airy beam for the first time. The formation and disappearance of the vortex can be modulated by the EIT effect. Also, the interference between the main lobe and side lobes leads to the energy redistribution of the Airy beam. We have found that with the change of the power and frequency detuning of the dressing field, the lobes of Airy beam will shift spatially due to the cross-Kerr effect. At the two-photon resonance point, the shift reaches its maximum. In addition, defocusing and focusing caused by self-Kerr effect happen in the lobes. Overall, the regulation of Airy vortex beam we have achieved by multi-parameters will play a significant part in the realm of complex optical micro-manipulation.