海绵
止血器
生物相容性
血栓弹性成像
止血剂
凝血酶
壳聚糖
粘附
明胶海绵
止血
化学
生物医学工程
血小板
外科
医学
生物化学
免疫学
植物
生物
栓塞
有机化学
作者
Lianyong Wang,Tongxing Zhang,Yadong Liu,Jingchen Zhang,Jiuxia Yang,Xuelei Li,Lianyong Wang
标识
DOI:10.1016/j.mtbio.2024.101031
摘要
Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for the effective management of uncontrolled coagulopathic hemorrhage remains a challenge. We here developed a chitosan-based sponge by integrating freeze-drying, chemical decoration of alkyl chains and phosphate groups, and physical loading of thrombin. The sponge exhibited high mechanical strength, self-elasticity, and rapid shape recovery. The sponge facilitated blood cell adhesion, aggregation, and activation through hydrophobic and electrostatic interactions, as well as accelerated blood clotting. The sponge exhibited higher efficacy than commercial gauze and gelatin sponge in managing uncontrolled hemorrhage from heparinized rat tail amputation, liver superficial injury, and liver perforating wound models. In addition, the sponge exhibited favorable biodegradability and biocompatibility. These findings revealed that the developed sponge holds great potential as a novel hemostat for effectively managing uncontrolled coagulopathic hemorrhage from superficial and perforating wounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI