内分泌学
内科学
淀粉样蛋白(真菌学)
β淀粉样蛋白
激素
慢波睡眠
BETA(编程语言)
多导睡眠图
睾酮(贴片)
睡眠(系统调用)
睡眠剥夺
睡眠阶段
快速眼动睡眠
阿尔茨海默病
医学
昼夜节律
心理学
疾病
神经科学
眼球运动
病理
脑电图
计算机科学
程序设计语言
操作系统
呼吸暂停
作者
Yevgenia Rosenblum,Mariana Pereira,Oliver Stange,Frederik D. Weber,Leonore Bovy,Sofia Tzioridou,Elisa Lancini,David A. Neville,Nadja Klein,Timo de Wolff,Mandy Stritzke,Iris Kersten,Manfred Uhr,Jurgen A.H.R. Claassen,Axel Steiger,Marcel M. Verbeek,Martin Dresler
摘要
Objective Recent evidence shows that during slow‐wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid‐beta protein. Poor sleep or elevated cortisol levels can worsen amyloid‐beta clearance, potentially leading to the formation of amyloid plaques, a neuropathological hallmark of Alzheimer disease. Here, we explored how nocturnal neural and endocrine activity affects amyloid‐beta fluctuations in the peripheral blood. Methods We acquired simultaneous polysomnography and all‐night blood sampling in 60 healthy volunteers aged 20–68 years. Nocturnal plasma concentrations of amyloid‐beta‐40, amyloid‐beta‐42, cortisol, and growth hormone were assessed every 20 minutes. Amyloid‐beta fluctuations were modeled with sleep stages, (non)oscillatory power, and hormones as predictors while controlling for age and participant‐specific random effects. Results Amyloid‐beta‐40 and amyloid‐beta‐42 levels correlated positively with growth hormone concentrations, SWS proportion, and slow‐wave (0.3–4Hz) oscillatory and high‐band (30–48Hz) nonoscillatory power, but negatively with cortisol concentrations and rapid eye movement sleep (REM) proportion measured 40–100 minutes previously (all t values > |3|, p values < 0.003). Older participants showed higher amyloid‐beta‐40 levels. Interpretation Slow‐wave oscillations are associated with higher plasma amyloid‐beta levels, whereas REM sleep is related to decreased amyloid‐beta plasma levels, possibly representing changes in central amyloid‐beta production or clearance. Strong associations between cortisol, growth hormone, and amyloid‐beta presumably reflect the sleep‐regulating role of the corresponding releasing hormones. A positive association between age and amyloid‐beta‐40 may indicate that peripheral clearance becomes less efficient with age. ANN NEUROL 2024;96:46–60
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