Efficacy and safety of different chemotherapy regimens concurrent with radiotherapy in the treatment of locally advanced cervical cancer

医学 顺铂 内科学 宫颈癌 紫杉醇 放化疗 外科肿瘤学 化疗 肿瘤科 放射治疗 不利影响 临床终点 癌症 随机对照试验
作者
Yaping Wu,Peng Jiang,Zhiying Chen,Wei Li,Bin Dong,Yongchun Zhang
出处
期刊:BMC Cancer [BioMed Central]
卷期号:24 (1) 被引量:1
标识
DOI:10.1186/s12885-024-12358-8
摘要

Abstract Background Evaluate the efficacy and safety of different chemotherapy regimens concurrent with radiotherapy in treating locally advanced cervical cancer (LACC). Methods Retrospective data was collected from LACC patients who were treated at our institution. These patients were categorized into three groups: the single-agent cisplatin (DDP) chemoradiotherapy group, the paclitaxel plus cisplatin (TP) chemoradiotherapy group, and the nanoparticle albumin-bound (nab-) paclitaxel combined with cisplatin (nPP) chemoradiotherapy group. The primary endpoints were overall survival (OS) and progression-free survival (PFS) and the secondary endpoints were objective response rate (ORR) and incidence of adverse events (AEs). Results A total of 124 patients were enrolled (32 in the DDP group, 41 in the TP group, and 51 in the nPP group). There were differences in OS ( P = 0.041, HR 0.527, 95% CI 0.314–0.884) and PFS ( P = 0.003, HR 0.517, 95% CI 0.343–0.779) between the three groups. Notably, the 2-year OS rate was significantly higher in the nPP group compared to the DDP group (92.2% vs. 85.4%, P = 0.012). The 2-year PFS rates showed a marked increase in the TP group (78.0% vs. 59.4%, P = 0.048) and the nPP group (88.2% vs. 59.4%, P = 0.001) relative to the DPP group, with multiple comparisons indicating that the 2-year PFS rate was significantly superior in the nPP group versus the DDP group (88.2% vs. 59.4%, P = 0.001). Moreover, the ORR was also significantly higher in the nPP group than in the DDP group ( P = 0.013); and no statistically significant differences were found in the incidence of AEs among the groups ( P > 0.05). Conclusions In LACC treatment, the two cisplatin-based doublet chemotherapy regimens are associated with better outcomes, with the nab-paclitaxel plus cisplatin regimen showing better efficacy than the paclitaxel plus cisplatin regimen. Furthermore, the AEs associated with these regimens were deemed tolerable. These findings could provide a reference for the clinical treatment of LACC. However, further prospective studies are needed to verify it.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
一只大憨憨猫完成签到,获得积分10
刚刚
JJ完成签到,获得积分10
刚刚
DrW完成签到,获得积分10
刚刚
隐形曼青应助yue采纳,获得10
1秒前
ccyy完成签到 ,获得积分10
1秒前
NexusExplorer应助腾腾腾采纳,获得10
2秒前
宿帅帅完成签到,获得积分10
3秒前
3秒前
Ningxin完成签到,获得积分10
3秒前
HHEHK发布了新的文献求助10
3秒前
柚子完成签到 ,获得积分10
3秒前
雨辰完成签到,获得积分10
5秒前
宿帅帅发布了新的文献求助10
5秒前
量子星尘发布了新的文献求助10
8秒前
8秒前
熠熠完成签到,获得积分10
8秒前
9秒前
zxzb完成签到,获得积分10
11秒前
苹果萧完成签到 ,获得积分10
14秒前
宋江他大表哥完成签到,获得积分10
14秒前
able发布了新的文献求助10
14秒前
王先生完成签到 ,获得积分10
15秒前
H.发布了新的文献求助10
15秒前
luoluo完成签到,获得积分10
16秒前
16秒前
高分子完成签到,获得积分10
16秒前
yian发布了新的文献求助10
17秒前
yar应助体贴凌柏采纳,获得10
18秒前
自由的雪一完成签到,获得积分10
18秒前
Ava应助李振博采纳,获得200
18秒前
JW发布了新的文献求助10
19秒前
无限的千凝完成签到 ,获得积分10
20秒前
CipherSage应助YeeYee采纳,获得10
20秒前
20秒前
Ander完成签到 ,获得积分10
21秒前
化白完成签到,获得积分10
22秒前
H.完成签到,获得积分10
22秒前
chuzihang完成签到 ,获得积分10
22秒前
科研小狗完成签到,获得积分10
28秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038303
求助须知:如何正确求助?哪些是违规求助? 3576013
关于积分的说明 11374210
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029