Inflammatory bowel disease and allergic diseases: A Mendelian randomization study

孟德尔随机化 医学 炎症性肠病 哮喘 溃疡性结肠炎 疾病 花粉热 免疫学 内科学 胃肠病学 基因型 生物化学 基因 化学 遗传变异
作者
Jiawei Li,Lijun Wang,Yuqi Ma,Yuan Liu
出处
期刊:Pediatric Allergy and Immunology [Wiley]
卷期号:35 (5) 被引量:2
标识
DOI:10.1111/pai.14147
摘要

Abstract Background Inflammatory bowel disease (IBD) and allergic diseases possess similar genetic backgrounds and pathogenesis. Observational studies have shown a correlation, but the exact direction of cause and effect remains unclear. The aim of this Mendelian randomization (MR) study is to assess bidirectional causality between inflammatory bowel disease and allergic diseases. Method We comprehensively analyzed the causal relationship between inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC) and allergic disease (asthma, Hay fever, and eczema) as a whole, allergic conjunctivitis (AC), atopic dermatitis (AD), allergic asthma (AAS), and allergic rhinitis (AR) by performing a bidirectional Mendelian randomization study using summary‐level data from genome‐wide association studies. The analysis results mainly came from the random‐effects model of inverse variance weighted (IVW‐RE). In addition, multivariate Mendelian randomization (MVMR) analysis was conducted to adjust the effect of body mass index (BMI) on the instrumental variables. Results The IVW‐RE method revealed that IBD genetically increased the risk of allergic disease as a whole (OR = 1.03, 95% CI = 1.01–1.04, fdr. p = .015), AC (OR = 1.04, 95% CI = 1.01–1.06, fdr. p = .011), and AD (OR = 1.06, 95% CI = 1.02–1.09, fdr. p = .004). Subgroup analysis further confirmed that CD increased the risk of allergic disease as a whole (OR = 1.02, 95% CI = 1.00–1.03, fdr. p = .031), AC (OR = 1.03, 95% CI = 1.01–1.05, fdr. p = .012), AD (OR = 1.06, 95% CI = 1.02–1.09, fdr. p = 2E−05), AAS (OR = 1.05, 95% CI = 1.02–1.08, fdr. p = .002) and AR (OR = 1.03, 95% CI = 1.00–1.07, fdr. p = .025), UC increased the risk of AAS (OR = 1.02, 95% CI = 0.98–1.07, fdr. p = .038). MVMR results showed that after taking BMI as secondary exposure, the causal effects of IBD on AC, IBD on AD, CD on allergic disease as a whole, CD on AC, CD on AD, CD on AAS, and CD on AR were still statistically significant. No significant association was observed in the reverse MR analysis. Conclusion This Mendelian randomized study demonstrated that IBD is a risk factor for allergic diseases, which is largely attributed to its subtype CD increasing the risk of AC, AD, ASS, and AR. Further investigations are needed to explore the causal relationship between allergic diseases and IBD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
MHCL完成签到 ,获得积分10
2秒前
哈基米德应助一颗小番茄采纳,获得30
2秒前
矮小的天菱完成签到,获得积分10
3秒前
长安发布了新的文献求助10
3秒前
6秒前
ddddddd完成签到,获得积分20
7秒前
章半仙完成签到,获得积分10
8秒前
9秒前
11秒前
amberzyc应助小远采纳,获得10
12秒前
qiongqiong完成签到,获得积分10
13秒前
淡定的依瑶完成签到,获得积分10
14秒前
江璃发布了新的文献求助10
16秒前
17秒前
18秒前
美丽的安珊完成签到,获得积分10
19秒前
19秒前
21秒前
Gilana完成签到,获得积分10
21秒前
xyh发布了新的文献求助10
21秒前
江璃完成签到,获得积分10
22秒前
TT发布了新的文献求助10
22秒前
美梦成真完成签到,获得积分10
23秒前
Gakay完成签到,获得积分10
23秒前
量子星尘发布了新的文献求助10
24秒前
szj完成签到,获得积分0
25秒前
旦皋完成签到,获得积分10
25秒前
赘婿应助花壳在逃野猪采纳,获得10
26秒前
卷卷完成签到,获得积分10
28秒前
JSY完成签到 ,获得积分20
28秒前
xyh完成签到,获得积分10
29秒前
小曾应助Florencia采纳,获得10
30秒前
神外王001完成签到 ,获得积分10
30秒前
35秒前
你是谁完成签到,获得积分10
36秒前
majf完成签到,获得积分10
37秒前
linhanwenzhou完成签到,获得积分10
37秒前
JSY关注了科研通微信公众号
37秒前
853225598完成签到,获得积分10
37秒前
798完成签到,获得积分10
38秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029