Sr-Incorporated Bioactive Glass Remodels the Immunological Microenvironment by Enhancing the Mitochondrial Function of Macrophage via the PI3K/AKT/mTOR Signaling Pathway

PI3K/AKT/mTOR通路 巨噬细胞 蛋白激酶B 细胞生物学 功能(生物学) 信号转导 化学 材料科学 生物 生物化学 体外
作者
Huanhuan Qiu,Huacui Xiong,Jiafu Zheng,Yuqi Peng,Chunhui Wang,Qing Hu,Fujian Zhao,Kexin Chen
出处
期刊:ACS Biomaterials Science & Engineering [American Chemical Society]
卷期号:10 (6): 3923-3934
标识
DOI:10.1021/acsbiomaterials.4c00228
摘要

The repair of critical-sized bone defects continues to pose a challenge in clinics. Strontium (Sr), recognized for its function in bone metabolism regulation, has shown potential in bone repair. However, the underlying mechanism through which Sr2+ guided favorable osteogenesis by modulating macrophages remains unclear, limiting their application in the design of bone biomaterials. Herein, Sr-incorporated bioactive glass (SrBG) was synthesized for further investigation. The release of Sr ions enhanced the immunomodulatory properties and osteogenic potential by modulating the polarization of macrophages toward the M2 phenotype. In vivo, a 3D-printed SrBG scaffold was fabricated and showed consistently improved bone regeneration by creating a prohealing immunological microenvironment. RNA sequencing was performed to explore the underlying mechanisms. It was found that Sr ions might enhance the mitochondrial function of macrophage by activating PI3K/AKT/mTOR signaling, thereby favoring osteogenesis. Our findings demonstrate the relationship between the immunomodulatory role of Sr ions and the mitochondrial function of macrophages. By focusing on the mitochondrial function of macrophages, Sr2+-mediated immunomodulation sheds light on the future design of biomaterials for tissue regenerative engineering.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
炙热的炳发布了新的文献求助10
刚刚
Caroline发布了新的文献求助10
1秒前
1秒前
123完成签到,获得积分10
1秒前
2秒前
rui发布了新的文献求助10
4秒前
4秒前
5秒前
九九九发布了新的文献求助10
5秒前
LJF发布了新的文献求助20
6秒前
暗流发布了新的文献求助10
6秒前
7秒前
龙飞凤舞发布了新的文献求助10
7秒前
8秒前
8秒前
9秒前
10秒前
诚心太君完成签到,获得积分10
10秒前
森sen完成签到 ,获得积分10
11秒前
11秒前
wanci应助小郭采纳,获得10
11秒前
11秒前
心灵美的花卷完成签到,获得积分10
13秒前
无名氏完成签到,获得积分10
15秒前
heheha发布了新的文献求助10
16秒前
16秒前
毕葛发布了新的文献求助20
17秒前
CC完成签到,获得积分20
17秒前
田様应助Ccc采纳,获得30
17秒前
18秒前
18秒前
Wang发布了新的文献求助10
19秒前
李健的小迷弟应助鲸鱼采纳,获得10
19秒前
LJF完成签到,获得积分0
19秒前
21秒前
爆米花应助海蓝青空采纳,获得10
21秒前
21秒前
Akim应助hmh采纳,获得10
21秒前
xiaoxiao发布了新的文献求助10
22秒前
22秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
Semiconductor Process Reliability in Practice 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
The Heath Anthology of American Literature: Early Nineteenth Century 1800 - 1865 Vol. B 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3233633
求助须知:如何正确求助?哪些是违规求助? 2880198
关于积分的说明 8214308
捐赠科研通 2547604
什么是DOI,文献DOI怎么找? 1377100
科研通“疑难数据库(出版商)”最低求助积分说明 647736
邀请新用户注册赠送积分活动 623173