再生障碍性贫血
端粒
癌症的体细胞进化
生物
免疫学
医学
遗传学
病毒学
基因
骨髓
出处
期刊:PubMed
日期:2024-06-01
卷期号:32 (3): 962-964
标识
DOI:10.19746/j.cnki.issn.1009-2137.2024.03.048
摘要
Studies have found that 1/3 patients with acquired aplastic anemia have shortened telomere length, and the shorter the telomere, the longer the disease course, the more prone to relapse, the lower the overall survival rate, and the higher the probability of clonal evolution. The regulation of telomere length is affected by many factors, including telomerase activity, telomerase-related genes, telomere regulatory proteins and other related factors. Telomere shortening can lead to genetic instability and increases the probability of clonal evolution in patients with acquired aplastic anemia. This article reviews the role of telomere in the clonal evolution of acquired aplastic anemia and factors affecting telomere length.
科研通智能强力驱动
Strongly Powered by AbleSci AI