Moderate resistance training reduces intermuscular adipose tissue and risk factors of atherosclerotic cardiovascular disease for elderly patients with type 2 diabetes

脂肪组织 2型糖尿病 阻力训练 医学 糖尿病 疾病 胰岛素抵抗 动脉粥样硬化性心血管疾病 内科学 心脏病学 内分泌学
作者
Fangli Tang,Wenjun Wang,Ying Wang,Yaujiunn Lee,Qingqing Lou
出处
期刊:Diabetes, Obesity and Metabolism [Wiley]
卷期号:26 (8): 3418-3428 被引量:1
标识
DOI:10.1111/dom.15684
摘要

Abstract Aim This study aimed to assess the impact of moderate resistance training on intermuscular adipose tissue (IMAT) in elderly patients with type 2 diabetes and the independent effect of IMAT reduction on metabolic outcomes. Methods In this randomized controlled trial, 85 patients with type 2 diabetes were assigned to either the resistance training group (42 participants) or the control group (43 participants) for a 6‐month intervention. The primary outcome was changes in IMAT measured by computed tomography scan and magnetic resonance imaging using the interactive decomposition of water and fat with echo asymmetry and least squares qualification sequence. Secondary outcomes included changes in metabolic parameters. Results Thirty‐seven participants in each group completed the study. The IMAT area (measured by a computed tomography scan) in the resistance group decreased from 5.176 ± 1.249 cm 2 to 4.660 ± 1.147 cm 2 , which is a change of −0.512 ± 0.115 cm 2 , representing a 9.89% decrease from the least‐squares adjusted mean at baseline, which was significantly different from that of the control group (a change of 0.587 ± 0.115 cm 2 , a 10.34% increase). The normal attenuation muscle area (representing normal muscle density) in the resistance group increased from 82.113 ± 8.776 cm 2 to 83.054 ± 8.761 cm 2 , a change of 1.049 ± 0.416 cm 2 , a 1.3% increase, which was significantly different from that of the control group (a change of −1.113 ± 0.416 cm 2 , a 1.41% decrease). Homeostasis model assessment 2 of beta cell function (HOMA2‐β; increased from 52.291 ± 24.765 to 56.368 ± 21.630, a change of 4.135 ± 1.910, a 7.91% increase from baseline) and ratio of insulin increase to blood glucose increase at 30 min after the oral glucose tolerance test (∆I30/∆G30; increased from 4.616 ± 1.653 to 5.302 ± 2.264, a change of 0.715 ± 0.262, a 15.49% increase) in the resistance group were significantly improved compared with those in the control group, which had a change of −3.457 ± 1.910, a 6.05% decrease in HOMA2‐β, and a change of −0.195 ± 0.262, a 3.87% decrease in ∆I30/∆G30, respectively. Adjusting for sex, age, diabetes duration, baseline IMAT, and the dependent variable at baseline, linear regression showed that the change in IMAT area was not related to the change in HOMA2 insulin resistance (β = −0.178, p = .402) or the change in HOMA2‐β (β = −1.891, p = .197), but was significantly related to the changes in ∆I30/∆G30 (β = −0.439, p = .047), 2‐h postprandial glucose (β = 1.321, p = .026), diastolic blood pressure (β = 2.425, p = .018), normal attenuation muscle area (β = −0.907, p = .019) and 10‐year risk of atherosclerotic cardiovascular disease (β = 0.976, p = .002). Conclusion Low‐level, moderate resistance training reduces IMAT content. Even a small reduction in IMAT may be related to a decrease in risk factors for atherosclerotic cardiovascular disease, but this small reduction may not be sufficient to reduce insulin resistance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
等待的凝芙完成签到,获得积分10
刚刚
读书的时候完成签到,获得积分10
刚刚
1秒前
共享精神应助jane采纳,获得10
1秒前
HD发布了新的文献求助10
2秒前
2秒前
Billie完成签到,获得积分10
2秒前
2秒前
3秒前
111发布了新的文献求助10
3秒前
FnDs完成签到,获得积分10
4秒前
未来完成签到,获得积分10
5秒前
不一样的烟火完成签到,获得积分10
5秒前
5秒前
时钟发布了新的文献求助10
6秒前
6秒前
等等完成签到,获得积分10
7秒前
Willow完成签到,获得积分10
7秒前
华仔应助弗洛莉娅采纳,获得10
7秒前
7秒前
nimo发布了新的文献求助20
7秒前
李健的粉丝团团长应助zz采纳,获得10
7秒前
8秒前
明明明明明明明明z完成签到,获得积分10
8秒前
Ray发布了新的文献求助10
8秒前
小溪溪发布了新的文献求助10
8秒前
青青完成签到,获得积分10
8秒前
9秒前
波波七发布了新的文献求助50
9秒前
9秒前
大模型应助安河桥采纳,获得10
9秒前
小欣完成签到,获得积分10
9秒前
LILI完成签到 ,获得积分20
10秒前
SC发布了新的文献求助10
10秒前
10秒前
amberxie发布了新的文献求助10
10秒前
上好佳发布了新的文献求助10
10秒前
HD完成签到,获得积分10
10秒前
SciGPT应助fyl采纳,获得10
11秒前
sino-ft完成签到,获得积分10
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969094
求助须知:如何正确求助?哪些是违规求助? 3514055
关于积分的说明 11171564
捐赠科研通 3249344
什么是DOI,文献DOI怎么找? 1794799
邀请新用户注册赠送积分活动 875377
科研通“疑难数据库(出版商)”最低求助积分说明 804779