丙烯醛
化学
脂质过氧化
荧光
下调和上调
GPX4
程序性细胞死亡
活性氧
生物化学
生物物理学
细胞生物学
细胞凋亡
氧化应激
谷胱甘肽
基因
酶
催化作用
物理
谷胱甘肽过氧化物酶
量子力学
生物
作者
Qingxia Duan,Yunpeng Wang,Xiaoli Zhang,Jie Han,Jin Yu,Jing Jing,Rubo Zhang,Jing Jing
标识
DOI:10.1021/acs.analchem.4c01690
摘要
Ferroptosis is a pattern of cell death caused by iron-dependent accumulation of lipid peroxides and is closely associated with the occurrence and development of multiple diseases. Acrolein (ACR), one of the final metabolites of lipid peroxidation, is a reactive carbonyl species with strong biotoxicity. Effective detection of ACR is important for understanding its role in the progression of ferroptosis and studying the specific mechanisms of ferroptosis-mediated diseases. However, visualization detection of ACR during ferroptosis has not yet been reported. In this work, the first ratiometric fluorescent probe (
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