自愈水凝胶
伤口愈合
材料科学
京尼平
生物医学工程
粘附
纳米技术
壳聚糖
化学
复合材料
外科
高分子化学
有机化学
医学
作者
Xiao Hu,Jia Zhi Zhu,Zhixin Hao,Letian Tang,Jian Sun,Wanru Sun,Jiaxiang Hu,Ping Yu Wang,Nicola Paccione Basmadji,José Luís Pedraz,Claudia Vairo,Esperanza Lafuente,Murugan Ramalingam,Shuyang Xie,Ranran Wang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2024-05-23
卷期号:25 (6): 3566-3582
被引量:1
标识
DOI:10.1021/acs.biomac.4c00205
摘要
Diabetic foot ulcers (DFUs), a prevalent complication of diabetes mellitus, may result in an amputation. Natural and renewable hydrogels are desirable materials for DFU dressings due to their outstanding biosafety and degradability. However, most hydrogels are usually only used for wound repair and cannot be employed to monitor motion because of their inherent poor mechanical properties and electrical conductivity. Given that proper wound stretching is beneficial for wound healing, the development of natural hydrogel patches integrated with wound repair properties and motion monitoring was expected to achieve efficient and accurate wound healing. Here, we designed a dual-network (chitosan and sodium alginate) hydrogel embedded with lignin–Ag and quercetin–melanin nanoparticles to achieve efficient wound healing and motion monitoring. The double network formed by the covalent bond and electrostatic interaction confers the hydrogel with superior mechanical properties. Instead of the usual chemical reagents, genipin extracted from Gardenia was used as a cross-linking agent for the hydrogel and consequently improved its biosafety. Furthermore, the incorporation of lignin–Ag nanoparticles greatly enhanced the mechanical strength, antibacterial efficacy, and conductivity of the hydrogel. The electrical conductivity of hydrogels gives them the capability of motion monitoring. The motion sensing mechanism is that stretching of the hydrogel induced by motion changes the conductivity of the hydrogel, thus converting the motion into an electrical signal. Meanwhile, quercetin–melanin nanoparticles confer exceptional adhesion, antioxidant, and anti-inflammatory properties to the hydrogels. The system ultimately achieved excellent wound repair and motion monitoring performance and was expected to be used for stretch-assisted safe and accurate wound repair in the future.
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