生物利用度
迷迭香酸
化学
咖啡酸
环糊精
羟基肉桂酸
阿魏酸
酚酸
药理学
生物化学
医学
抗氧化剂
作者
Kleyton Santos Veras,Flávia Nathiely Silveira Fachel,Valquíria Linck Bassani,Hélder Ferreira Teixeira,L. Koester
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-11-20
卷期号:14 (11): 2530-2530
被引量:5
标识
DOI:10.3390/pharmaceutics14112530
摘要
Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs.
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