Expanding past ZIF-8: Biomimetic mineralization using other MOFs

The development of protective metal-organic framework (MOF) coatings on the surface of natively folded proteins has emerged as a promising approach to enhance their stability. Zeolitic imidazolate frameworks have been the primary focus owing to their stability and ability to form in water. However, recent research has expanded the range of MOFs that can be synthesized under biocompatible conditions. This preview highlights the work of Yang, Giménez-Marqués, Ren, and others, showcasing novel efforts that provide a new direction for future research. These developments may lead to stable and robust biomolecules with broad applications in biomedicine and beyond. The development of protective metal-organic framework (MOF) coatings on the surface of natively folded proteins has emerged as a promising approach to enhance their stability. Zeolitic imidazolate frameworks have been the primary focus owing to their stability and ability to form in water. However, recent research has expanded the range of MOFs that can be synthesized under biocompatible conditions. This preview highlights the work of Yang, Giménez-Marqués, Ren, and others, showcasing novel efforts that provide a new direction for future research. These developments may lead to stable and robust biomolecules with broad applications in biomedicine and beyond.