体内
转移
癌症研究
体外
纳米载体
癌症
化学
医学
生物
药理学
生物化学
内科学
药品
生物技术
作者
Shuchang Wang,Lulu Wo,Zizhen Zhang,Chunchao Zhu,Chaojie Wang,Yangyang Wang,Lechun Hou,Hui Cao,Qian Zhao,Enyue Zhao
出处
期刊:Cancer Letters
[Elsevier]
日期:2022-11-01
卷期号:549: 215916-215916
被引量:10
标识
DOI:10.1016/j.canlet.2022.215916
摘要
Peritoneal metastasis is one of the common forms of metastasis in gastric cancer (GC). In this study, we identified the expression pattern of LINC00589 in GC patients and investigate the biological function in GC cells. RNA-pulldown assay was performed to explore the underlying molecular mechanism. Further, we utilize polyethyleneimine-modified mesoporous silica nanoparticles (PMSNs) as the nanocarriers for delivery of LINC00589 encoding plasmid and tested its therapeutic potential for GC with peritoneal dissemination. We revealed that LINC00589 was downregulated in GC tissues and suppressed the metastatic ability of GC cells. Mechanistically, LINC00589 exerted tumor suppressive function by promoting hnRNPA1 protein ubiquitination and proteasomal degradation, thus blocking alternative splicing of PKM to PKM2. Furthermore, LINC00589 delivered by PMSNs could suppress the peritoneal metastasis of GC in vivo and in vitro. This work may provide a new treatment option in GC peritoneal metastasis.
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