Day of trophectoderm biopsy and embryo quality are associated with outcomes following euploid embryo transfer

活产 胚胎移植 流产 胚胎 男科 胚泡 胚胎质量 活检 医学 妇科 妊娠率 生殖医学 单胚胎移植 低温保存 生物 怀孕 体外受精 病理 胚胎发生 细胞生物学 遗传学
作者
Charles A. Gordon,Andrea Lanes,Ann Thomas,Catherine Racowsky
出处
期刊:Journal of Assisted Reproduction and Genetics [Springer Nature]
卷期号:39 (11): 2539-2546 被引量:1
标识
DOI:10.1007/s10815-022-02613-x
摘要

PurposeTo compare clinical outcomes following transfer of euploid blastocysts of varying quality biopsied on day 5 versus day 6.MethodsRetrospective cohort study to evaluate embryo transfer outcomes for women undergoing autologous cryopreserved next generation sequencing euploid single embryo transfer from 10/2015 to 2/2022 at an academic IVF program. The primary outcome was live birth rate (LBR). Secondary outcomes included ongoing pregnancy rate (OPR), implantation rate (IR), and miscarriage rate (SAB rate).ResultsFive hundred and fifty-five transfers from 418 patients were analyzed. Euploid embryos biopsied on day 5 resulted in higher LBR compared to those biopsied on day 6 (62.3% vs. 49.6%; aRR 0.81 95% CI 0.65–0.996). When stratified by biopsy day and blastocyst quality, there was no difference in IR, OPR, and SAB rate for good, fair, and poor quality blastocysts biopsied on day 5 versus day 6. However, day 5 good quality embryos were associated with a higher LBR compared to day 6 good quality embryos (74.3% vs. 51.3%; aRR 0.69; 95% CI 0.48–0.999). There were no significant differences in LBR for fair and poor quality embryos biopsied on day 5 versus day 6.ConclusionOverall LBR are higher for euploid embryos biopsied on day 5 versus day 6. When stratified by embryo quality and day of biopsy, LBR are significantly higher for good quality day 5 versus day 6 embryos. When choosing between multiple euploid embryos, day 5 biopsied good quality embryos should be preferentially selected for transfer over day 6 embryos of the same quality.
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