子宫内膜
生物
转录组
胚胎
基因
免疫系统
男科
植入失败
内科学
免疫学
遗传学
内分泌学
怀孕
医学
基因表达
不育
作者
Peigen Chen,Jia Lu,Yi Zhou,Yingchun Guo,Cong Fang,Tingting Li
标识
DOI:10.1007/s10815-022-02573-2
摘要
To learn about the interaction between endometrial microbiota and host gene regulation in recurrent implantation failure.The endometrial microbiota of 111 patients (RIF, 75; CON, 36) was analyzed by using 16 s rRNA sequencing technology. Transcriptome sequencing analysis of the endometrial of 60 patients was performed by using high-throughput sequencing.We found that the structure and composition of endometrium microbiota community of RIF patients were significantly different from those in control group. The abnormality of microbial structure and composition might interfere with the implantation of embryos by affecting the immune adaptation of the endometrium and the formation of endometrial blood vessels.Our research described the host-microbe interaction in RIF. The structure and composition of endometrium microbiota community of RIF patients were significantly different from those in CON group. The abnormality of microbial structure and composition might interfere with the implantation of embryos by affecting the immune adaptation of the endometrium and the formation of endometrial blood vessels.
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