化学
咪唑
亲核细胞
催化作用
产量(工程)
合理设计
组合化学
亲核加成
有机化学
药物化学
纳米技术
冶金
材料科学
作者
Zhenfeng Zhang,Fang Xie,Jia Jia,Wanbin Zhang
摘要
A new type of chiral bicycle imidazole nucleophilic catalyst was rationally designed, facilely synthesized, and successfully applied in an asymmetric Steglich rearrangement with good to excellent yield and enantioselectivity at ambient temperature. Moreover, it can be easily recycled with almost no reduction of catalytic efficiency. This is the first example for the successful chiral imidazole nucleophilic catalyst without H-bonding assistance.
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