光动力疗法
单线态氧
材料科学
肿瘤缺氧
小泡
生物物理学
光化学
纳米医学
肿瘤消融
光热治疗
纳米载体
辐照
光敏剂
氧气
纳米颗粒
纳米技术
化学
膜
烧蚀
放射治疗
生物化学
有机化学
医学
生物
物理
核物理学
内科学
作者
Junjie Li,Kai Wei,Shuai Zuo,Yixuan Xu,Zengshi Zha,Wendong Ke,Huabing Chen,Zhishen Ge
标识
DOI:10.1002/adfm.201702108
摘要
Smart nanocarriers are of particular interest for highly effective photodynamic therapy (PDT) in the field of precision nanomedicine. Nevertheless, a critical challenge still remains in the exploration of potent PDT treatment against hypoxic tumor. Herein, light‐triggered clustered polymeric vesicles for photoinduced hypoxic tumor ablation are demonstrated, which are able to deeply penetrate into the tumor and simultaneously afford oxygen supply upon light irradiation. Hydrogen peroxide (H 2 O 2 ) and poly(amidoamine) dendrimer conjugating chlorin e6/cypate (CC‐PAMAM) are coassembled with reactive‐oxygen‐species‐responsive triblock copolymer into the polymeric vesicles. Upon 805 nm irradiation, the vesicles exhibit the light‐triggered thermal effect that is able to decompose H 2 O 2 into O 2 , which distinctly ensures the alleviation of tumor hypoxia at tumor. Followed by 660 nm irradiation, the vesicles are rapidly destabilized through singlet oxygen‐mediated cleavage of copolymer under light irradiation and thus allow the release of photoactive CC‐PAMAM from the vesicular chambers, followed by their deep penetration in the poorly permeable tumor. Consequently, the light‐triggered vesicles with both self‐supplied oxygen and deep tissue penetrability achieve the total ablation of hypoxic hypopermeable pancreatic tumor through photodynamic damage. These findings represent a general and smart nanoplatform for effective photoinduced treatment against hypoxic tumor.
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