肽
临床试验
药理学
药物发现
药品
药物开发
计算生物学
医学
化学
纳米技术
生物信息学
生物
生物化学
材料科学
作者
Keld Fosgerau,Torsten Hoffmann
标识
DOI:10.1016/j.drudis.2014.10.003
摘要
Peptides are recognized for being highly selective and efficacious and, at the same time, relatively safe and well tolerated. Consequently, there is an increased interest in peptides in pharmaceutical research and development (R&D), and approximately 140 peptide therapeutics are currently being evaluated in clinical trials. Given that the low-hanging fruits in the form of obvious peptide targets have already been picked, it has now become necessary to explore new routes beyond traditional peptide design. Examples of such approaches are multifunctional and cell penetrating peptides, as well as peptide drug conjugates. Here, we discuss the current status, strengths, and weaknesses of peptides as medicines and the emerging new opportunities in peptide drug design and development.
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