医学
自身抗体
抗体
免疫学
结缔组织病
全身性疾病
疾病
红斑狼疮
相关性
内科学
免疫病理学
自身免疫性疾病
几何学
数学
作者
Adla B. Hassan,Ingrid E. Lundberg,David Isenberg,Marie Wahren‐Herlenius
标识
DOI:10.1080/rhe.31.3.133.139
摘要
Objective: To investigate the temporal correlation between anti-Ro/SSA and anti-La/SSB antibody levels and compare them with variation in clinical disease activity in patients with systemic lupus erythematosus (SLE). Methods: Sequential serum samples collected over 18-44 months from 18 anti-Ro/SSA positive patients with systemic lupus erythematosus were analysed by ELISA with recombinant Ro60, Ro52 and La antigens. Disease activity was assessed by the BILAG index. Results: Limited antibody level variation over time was found in most patients, but a subset displayed more changes and a co-variation between the levels of separate specificities was found in 40% of patients. In two patients antibody levels fluctuated with the global score. Antibodies also correlated with separate organ/systems involvment in individual patients. Conclusion: The Ro60, Ro52 and La antibody profile is fixed at an early stage of disease and in most patients hardly changes. Patients with fluctuating levels tend to have a co-ordinated expression of these autoantibodies.
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