Review on the Discovery of New Benzimidazole Derivatives as Anticancer Agents: Synthesis and Structure-activity Relationship (2010-2022)

苯并咪唑 化学 组合化学 药物发现 分子 戒指(化学) 计算生物学 纳米技术 立体化学 有机化学 生物化学 生物 材料科学
作者
Km Shabana,Salahuddin Salahuddin,Avijit Mazumder,Rajnish Kumar,Vimal Datt,Sonakshi Tyagi,Mohammad Shahar Yar,Mohamed Jawed Ahsan,Mohammad Sarafroz
出处
期刊:Letters in Drug Design & Discovery [Bentham Science]
卷期号:21 (3): 451-479 被引量:4
标识
DOI:10.2174/1570180820666221017155955
摘要

Background: Benzimidazole (Benz-fused bicyclic ring system) is the most versatile class of heterocyclic compounds due to its numerous applications in industrial and synthetic organic chemistry because of its many biological actions. Benzimidazole analogs have been used to discover various medical problems, such as cancer, bacterial infections, fungi infections, etc. Researchers are studying nitrogencontaining hybrid heterocyclic compounds because they provide a broad range of therapeutic potential and have minimal side effects. Objective: The current literature review emphasizes recent developments in the design of new benzimidazole derivatives as possible anticancer agents with their relationship between structure and activity, which will give insight into the future design of more active benzimidazole molecules. Results: The present review consists of synthetic protocols for the synthesis of benzimidazole derivatives along with their pharmacological potentials and structure-activity relationship in correlation with synthetic molecules to provide a depth view of the work done on benzimidazole. Conclusion: It would be significant for further research in developing better drug molecules representing a potent derivative of medicinal agents.
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