大蠊
伤口愈合
医学
细胞生长
激活剂(遗传学)
车站3
癌症研究
免疫学
信号转导
化学
细胞生物学
生物
受体
内科学
蟑螂
生态学
生物化学
作者
Zheng Liang,Guangming Han,Zecheng Luo,Baojie Li,Wentao Liu,Chongyang Shen
标识
DOI:10.3389/fphar.2022.920855
摘要
Cutaneous-wound healing requires a coordinated reaction of multiple cells, including interstitial cells. Impaired recovery of cutaneous wounds can lead to various adverse health outcomes. Kangfuxin (KFX), an extract obtained from Periplaneta americana, is beneficial in cutaneous-wound healing. In this study, we isolated dermal cells from suckling mice and established a mouse model of cutaneous injury to evaluate the therapeutic effects of KFX. Cell biology experiments indicated that treatment with KFX improved cell proliferation and migration and also repaired cutaneous wounds in the animal model. Activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway was the core molecular mechanism of KFX. Our study provides a theoretical and practical basis for the clinical application of KFX in cutaneous-wound healing.
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