Exploring the Crucial Role of Plant Growth-Promoting Rhizobacteria (PGPR) in Plant Secondary Metabolite Production and Diabetes Management

Natural products in the form of secondary metabolites have been applied for healing several ailments since prehistoric times. Secondary metabolites obtained from the medicinal plants are one of the main sources used as antidiabetic medicines. Diabetes mellitus is a group of metabolic orders remarked by hyperglycemia and disturbances in carbohydrate, fat, and protein metabolic processes. Diabetes is connected with insufficient insulin secretion by pancreatic β-cells or dubious insulin activity in insulin signal transduction. Plants can produce secondary metabolites with the help of plant growth-promoting rhizobacteria (PGPR). PGPR in colonies induce plant development by synthesizing indole-3-acetic acid, cytokine, and gibberellin hormones, making the soil rich in mineral nitrogen and also combating pathogenic microorganisms to protect their host plants. There is an indirect connection between PGPR and diabetes treatments. The vital role of PGPR in secondary metabolite production is making plants rich in bioactive compounds which consequently act as antidiabetic drug molecules. Many research papers have been published regarding ethnopharmacology of antidiabetes plants, but the involvement of PGPR in diabetes management still remained to be researched. The chapter consolidates the articles published in indexed journals describing the role played by PGPR in medicinal plants to produce bioactive compounds as secondary metabolites and their effectiveness in amending diabetes interventions.