再生(生物学)
斑马鱼
细胞生物学
调节器
增强子
细胞外基质
生物
基质金属蛋白酶
转录因子
遗传学
基因
作者
Ivana Zlatanova,Fei Sun,Roland S. Wu,X Chen,Bryan H. Lau,Pauline Colombier,Tanvi Sinha,Barbara Celona,Shan-Mei Xu,Stefan C. Materna,Guo N. Huang,Brian L. Black
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-11-29
卷期号:9 (48)
被引量:7
标识
DOI:10.1126/sciadv.adh5313
摘要
Mammals have limited capacity for heart regeneration, whereas zebrafish have extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells promote cardiomyocyte cell cycle reentry and myocardial repair, but the mechanisms responsible for promoting an injury microenvironment conducive to regeneration remain incompletely defined. Here, we identify the matrix metalloproteinase Mmp14b as an essential regulator of heart regeneration. We identify a TEAD-dependent mmp14b endothelial enhancer induced by heart injury in zebrafish and mice, and we show that the enhancer is required for regeneration, supporting a role for Hippo signaling upstream of mmp14b . Last, we show that MMP-14 function in mice is important for the accumulation of Agrin, an essential regulator of neonatal mouse heart regeneration. These findings reveal mechanisms for extracellular matrix remodeling that promote heart regeneration.
科研通智能强力驱动
Strongly Powered by AbleSci AI