酯酶
生物
基因
丝氨酸
丝氨酸水解酶
抗生素耐药性
抗菌剂
鉴定(生物学)
微生物学
微生物群
计算生物学
遗传学
生物化学
酶
抗生素
植物
作者
Poonam Dhindwal,Charis Thompson,Daniel Kos,Koa Planedin,Richa Jain,Murray Jelinski,Antonio C. Ruzzini
标识
DOI:10.1073/pnas.2219827120
摘要
The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.
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