蓝斑
神经科学
基因座(遗传学)
心理学
医学
生物
中枢神经系统
遗传学
基因
作者
Li‐Ping Tsai,Da-Zhong Luo,Hao Chan,Wei‐Chen Hung,Wen‐Sung Lai,Ming‐Yuan Min,Shi‐Bing Wong
标识
DOI:10.1016/j.expneurol.2024.114927
摘要
Prader-Willi syndrome (PWS) is a multisystemic disorder. Notably, many characteristic symptoms of PWS are correlated with locus coeruleus norepinephrine system (LC-NE) dysfunction, including impairment in arousal, learning, pain modulation, and stress-induced negative affective states. Although electrophysiological experiments in necdin-deficient mice, an established PWS animal model, have revealed decreased spontaneous neuronal firing activity in the LC and impaired excitability, the behavioral phenotypes related to LC-NE dysfunction remain unexplored. In this study, heterozygous necdin-deficient mice (B6.Cg-Ndn
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