痛风
髋部骨折
医学
他汀类
内科学
心脏病学
骨质疏松症
作者
Chun‐Ming Chen,Wan‐Ting Huang,Sheng‐Feng Sung,Chih‐Cheng Hsu,Yueh‐Han Hsu
出处
期刊:Bone reports
[Elsevier]
日期:2024-09-01
卷期号:22: 101799-101799
标识
DOI:10.1016/j.bonr.2024.101799
摘要
Studies show that statins users are at reduced risk of fracture and improved bone mineral density. However, the clinical effectiveness of statin use in patients with gout has not been investigated. This retrospective cohort study used data from Taiwan's National Health Insurance Research Database, consisting of 3443 patients with gout using statins aged 50 years and above and 6886 gout patients of non-statin users matched by sex, age and propensity score. The Cox proportional hazards regression analysis showed that statin use was associated with a reduced risk of hip fracture (adjusted hazard ratio [aHR] = 0.78, 95 % confidence interval [CI] = 0.64-0.94) after controlling for potential confounding factors. The association was significant in both genders aged 50-64 years, with aHRs of near 0.35, but not in the elderly. In addition, women aged 50-64 years who used statins also exhibited a lower risk of vertebral fracture (aHR = 0.70, 95 % CI = 0.50-0.99), but not men. In conclusion, the stating use in gout patients could reduce fracture risk for younger patients. Further research is warranted to confirm these findings.
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