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Placental Transcriptomic Signatures of Prenatal Phthalate Exposure and Identification of Placenta-Brain Genes Associated with the Effects of Phthalate Exposure on Neurodevelopment in Children

邻苯二甲酸盐 胎盘 鉴定(生物学) 转录组 怀孕 生物 基因 胎儿 生物信息学 遗传学 化学 基因表达 生态学 有机化学
作者
Jiawen Ren,Yifan Wang,Yimin Zhang,Heyue Jin,Jingjing Cheng,Fangbiao Tao,Yumin Zhu
出处
期刊:Environmental Science & Technology [American Chemical Society]
卷期号:58 (43): 19141-19151
标识
DOI:10.1021/acs.est.4c04082
摘要

Prenatal exposure to phthalates may affect placental function and fetal development, but the underlying mechanisms are unclear. The aim of our study was to explore the alterations in the placental transcriptome associated with prenatal phthalate exposure and to further analyze whether the placental-brain axis (PBA) genes play a mediating role in the association between prenatal phthalate exposure and children's neurodevelopment. We included 172 participants from the Ma'anshan Birth Cohort and collected data on seven phthalate metabolites in urine during pregnancy, placental tissue RNA-seq, and neurodevelopment of offspring. Bioinformatics analysis revealed that aberrant regulation of the placental transcriptome was associated with prenatal phthalate exposure. Exposure to phthalates during pregnancy was found to be associated with neurodevelopmental delay in children aged 6, 18, and 48 months using the multiple linear regression model. Meanwhile, employing mediation analysis, nine PBA genes were identified that mediate the association between exposure to phthalates during pregnancy and the neurodevelopment of children. Our study will provide a basis for potential mechanisms by which prenatal exposure to phthalates affects placental function and children's neurodevelopment.
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