Enantioselective C–C bond formation in complex multicatalytic systems

In recent years, multicatalysis has evolved into an attractive strategy for the synthesis of complex molecules from simple starting materials. Multicatalysis can either facilitate existing synthetic methods by reducing time, waste and cost or enable new transformations that are impossible using classic approaches. This chapter introduces three different categories of multicatalysis (cooperative, domino, and relay catalysis). The classification is based on the number of catalysts used for a transformation and how their respective catalytic cycles interact with one another. The opportunities introduced by each category are discussed and illustrated with selected examples in the context of enantioselective C–C bond formation reactions. Lastly, a brief discussion of “complex systems”, i.e., systems of higher complexity beyond the aforementioned classification, is provided.