环糊精
药物输送
超分子化学
药品
溃疡性结肠炎
抗氧化剂
材料科学
控制释放
药理学
纳米技术
化学
生物化学
医学
有机化学
内科学
分子
疾病
作者
Haiting Xu,Linxin Dai,Wenbiao Nie,Rui Luo,Xiulan Pu,Lingling Dong,Qiyan Chen,Shanshan Qi,Xiaoqin Han,Jieshu You,Jinming Zhang,Fei Gao
标识
DOI:10.1016/j.matdes.2023.111606
摘要
Cyclodextrins (CDs) have been applied widely as an oral micro-nano drug delivery material for the treatment of ulcerative colitis (UC) because of their stability around the stomach. However, the further application of CDs is hindered due to their inherent poor targeting and controlled release properties. In this study, CD-supramolecular nanoparticles ([email protected]) were developed based on the structural characteristics of CDs (e.g., multi-group modifiability and hydrophobic cavity) to encapsulate rhein (RH) for oral delivery against UC. The [email protected] showed an average size of 154.70 ± 1.80 nm and exhibited high encapsulation efficiency (95.55 ± 2.37 %). When incubated in simulated gastric fluid for 2 h, [email protected] only released 20.3 ± 0.47 % RH due to the protection of supramolecular effects of CDs. However, RH was rapidly released from [email protected] (released 66.3 ± 2.50 %) after H2O2 was treated with the assistance of the ROS-sensitive properties. Moreover, [email protected] were taken up by macrophages in 1.5 times higher amounts than preparations which did not have CD44-targeted effects. Notably, the results showed that [email protected] with an accurate on-demand drug release strategy achieved the best anti-inflammatory and antioxidant effects, and they are expected to be a promising carrier in the UC treatment.
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