月经周期
黄体期
卵泡期
生理学
尼古丁
激素
医学
压力源
排卵
内科学
心理学
内分泌学
雌激素
临床心理学
作者
Ashley R. Ethier,Laurie Sykes Tottenham,Jyotpal Singh,J. Patrick Neary,Jarosław Piskorski,Jennifer L. Gordon
出处
期刊:Behavioural Pharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-06-24
卷期号:34 (5): 287-298
标识
DOI:10.1097/fbp.0000000000000734
摘要
Women experience greater difficulties in quitting smoking than men, though the hormonal factors contributing to this sex difference remain to be clarified. The current study aimed to examine menstrual cycle effects on smoking cue-induced cravings as well as examine dynamic reproductive hormone change as a potential mediator underlying any cycle effects observed. Twenty-one women who smoke underwent two laboratory sessions – one in the mid-follicular phase and the other in the late luteal phase – involving an in-vivo smoking cue task, administered before and after exposure to a psychosocial laboratory stressor. Heart rate variability (HRV) and subjective smoking cravings were assessed in response to the cue task. The degree of change in the urinary metabolites of estradiol and progesterone from 2 days before to the day of each laboratory session was measured. Results revealed that both before and following exposure to psychosocial stress, highly nicotine-dependent women exhibited smaller cue-induced increases in HRV relative to the follicular phase. In contrast, less nicotine-dependent women exhibit an increase in HRV in both menstrual cycle phases. Results furthermore suggest that menstrual cycle effects seen in highly nicotine-dependent women are driven by the decline in estradiol and progesterone occurring in the late luteal phase. Though limited by a small sample size, this study suggests that withdrawal from reproductive hormones in the late luteal phase may alter highly nicotine-dependent women’s physiological response to smoking cues, which may reflect greater difficulty resisting temptation. These findings may provide some insight regarding women’s greater difficulty in maintaining abstinence after quitting smoking.
科研通智能强力驱动
Strongly Powered by AbleSci AI