Abstract The main component of Silicone-based heat transfer fluids is modified silicone oil. The high and low using temperature of silicone-based heat transfer fluids is better than hydrocarbon organic heat transfer fluids. The raising of the maximum using temperature means that it can obtain higher temperature steam in the heat transfer process of the system, and the power generation efficiency of the turbine will be improved remarkably if the silicone-based heat transfer fluids are used in parabolic through the solar power system. It can also increase the efficiency of a solar thermal power plant, so silicone-based heat transfer fluids will be the new type of heat transfer medium. The paper compares these two mediums in terms of structure, composition, and deterioration and introduces the using performance and synthesis method of Silicone. The status of Silicone and problems of application are also presented.