1287P A clinical controlled study of fecal microbiota transplantation in the treatment of advanced cancer with cachexia

Cachexia is one of the most common complications of advanced tumors. About 20 % of patients with malignant tumors die from cachexia.It has been proved that the intestinal microecological environment can be improved by fecal microbiota transplatation to improve the nutritional status of patients.Therefore, we suggest that for patients with cachexia, the use of fecal microbiota transplatation on the basis of standardized nutrition therapy can improve the nutritional status of patients, improve the quality of life of patients. A total of 20 patients with terminal tumor complicated with cachexia were included in the study.According to the propensity score principle, all the selected subjects were divided into the experimental group (10 cases) and the control group (10 cases ).The control group was only given standardized nutrition therapy, and the experimental group was given fecal microbiota transplatation on the basis of standardized nutrition therapy. The paired T test was used to analyze and compare the differences in skeletal muscle, protein, body mass index, hemoglobin, albumin, prealbumin, and triglyceride between the two groups before and after treatment, and the changes in cytokines in the experimental group before and after treatment. There was no statistically significant difference in hemoglobin and other indicators between the two groups before intervention(P>0.05).The skeletal muscle, protein, body mass index, hemoglobin, albumin and prealbumin in the experimental group after transplantation were statistically significant compared with those before transplantation and those in the control group(P<0.05).There was no significant difference in BMI and triglyceride between the experimental group and the control group before and after transplantation(P>0.05).IL-2, IL-6, TNF-α and IFN-γ in the experimental group were significantly higher than those before transplantation(P<0.05). For patients with advanced cancer complicated with cachexia, fecal microbiota transplatation of healthy people can significantly improve the nutritional status of patients, increase nutritional intake, improve the quality of life, which has clinical significance and application value.