溃疡性结肠炎
封堵器
医学
失调
结肠炎
炎症性肠病
势垒函数
汤剂
治疗效果
药理学
肠道菌群
紧密连接
胃肠病学
内科学
疾病
免疫学
化学
生物
细胞生物学
生物化学
作者
Hao Wei,Zhejie Chen,Li‐Ju Wang,Qin Yuan,Caifang Gao,Meiling Ma,Congsheng Liu,Yitao Wang,Shengpeng Wang
出处
期刊:Phytomedicine
[Elsevier]
日期:2022-09-21
卷期号:107: 154468-154468
被引量:8
标识
DOI:10.1016/j.phymed.2022.154468
摘要
Ulcerative colitis (UC) has affected an increasing number of people globally, with still limited clinical success. Huanglian Decoction (HLD) is a famous classical prescription documented for alleviating gastrointestinal disorders with unexplored therapeutic effects and mechanisms.This study aimed to investigate the therapeutic effect and underlying mechanism of HLD in dextran sodium sulfate (DSS)-induced colitis mice.The efficacy and safety of HLD were evaluated in a well-established DSS-induced colitis mice model. Disease progression was monitored via clinical symptoms, histopathological examination, biochemical assays, and epithelial barrier function evaluation.HLD alleviated DSS-induced colitis symptoms, reversed colon length reduction, reduced histological injury, downregulated the level of pro-inflammatory cytokines, maintained the tight distribution of ZO-1/occludin-1 and the normal level of β-catenin, concurrent with apoptosis reduction in the colonic epithelium. After HLD treatment, the DSS-induced gut dysbiosis was modulated, and the gut microbiota achieved a new equilibrium state.This study demonstrates that HLD may present a potential remedy for UC treatment, providing evidence for further developing Chinese classical prescriptions.
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