Technological advances and challenges for exploring attribute transmission in tablet development by high shear wet granulation

High shear wet granulation and tableting (HSWG-T) are complex pharmaceutical processes, which makes tablet quality be influenced by many variables including raw material attributes, process variables, and intermediate granule properties. To achieve the desired final quality of tablets and improve the production efficiency, it is necessary and urgent to comprehensively understand the attribute transmission pattern in HSWG-T. However, this aspect seems to be unexpectedly ignored in terms of reviews published so far. Therefore, it is the major focus in this review and was summarized and discussed based on the quality by design (QbD) concept. Additionally, the applications of characterization techniques and current multivariate analysis models in the study of attribute transmission pattern were also reviewed. As expected, there are some certain attribute transmission patterns in HSWG-T. Moreover, some attributes are highly correlated, and their interactions are also important for the results. Therefore, this review is beneficial for QbD in HSWG-T. It can also provide some guidance for further studies.