小干扰RNA
基因沉默
RNA干扰
基因敲除
机制(生物学)
核酸酶
作用机理
细胞生物学
RNA沉默
生物
基因
核糖核酸
计算生物学
遗传学
体外
认识论
哲学
作者
Walhan Alshaer,Hadil Zureigat,Arwa Al Karaki,Abdulfattah Al-Kadash,Lobna Gharaibeh,Ma’mon M. Hatmal,Alaa A. A. Aljabali,Abdalla Awidi
标识
DOI:10.1016/j.ejphar.2021.174178
摘要
Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious, hemato-oncological, cardiovascular, and neurodegenerative conditions. The mechanism of action of small interfering RNA (siRNA) is based on post-transcriptional gene silencing. siRNA molecules are usually specific and efficient in the knockdown of disease-related genes. However, they are characterized by low cellular uptake and are susceptible to nuclease-mediated degradation. Therefore, siRNAs require a carrier for their protection and efficient delivery into target cells. The current review highlights the siRNA-based mechanism of action, challanges, and recent advances in clinical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI