癌症研究
癌细胞
癌症
遗传增强
基因
RNA干扰
抗药性
小RNA
医学
生物
内科学
遗传学
核糖核酸
作者
Jinliang Gao,Tao Luo,Jinke Wang
标识
DOI:10.1038/s41467-021-25632-1
摘要
Abstract Although some effective therapies have been available for cancer, it still poses a great threat to human health and life due to its drug resistance and low response in patients. Here, we develop a ferroptosis-based therapy by combining iron nanoparticles and cancer-specific gene interference. The expression of two iron metabolic genes ( FPN and LCN2 ) was selectively knocked down in cancer cells by Cas13a or microRNA controlled by a NF-κB-specific promoter. Cells were simultaneously treated by iron nanoparticles. As a result, a significant ferroptosis was induced in a wide variety of cancer cells. However, the same treatment had little effect on normal cells. By transferring genes with adeno-associated virus and iron nanoparticles, the significant tumor growth inhibition and durable cure were obtained in mice with the therapy. In this work, we thus show a cancer therapy based on gene interference-enhanced ferroptosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI