Multicomponent Domino Synthesis of Highly Functionalized Aryl and Heteroaryl Fused Pyrroloquinolinone Ring Systems via Environmentally Benign Solid‐state Melt Reaction

Synthesis of structurally diverse fused polycyclic pyrroloquinolinone hybrids in good to excellent yields employing domino multicomponent reaction sequence has been achieved. The reaction sequence involves 1,3-dipolar cycloaddition and subsequent double annulation reaction process. Baylis-Hillman adducts prepared from various aryl/heteroaryl aldehyde were used as dipolarophiles, while the 1,3-dipole components were azomethine ylides generated in situ from isatin and different α-amino acids. The reaction is highly regio- and stereoselective, atom economic and environmentally benign in nature.