心肌保护
脂质过氧化
再灌注损伤
药理学
心肌缺血
材料科学
纳米颗粒
缺血
氧化应激
医学
心脏病学
纳米技术
内科学
作者
Yabing Zhang,Xiangyi Ren,Yan Wang,Dongxu Chen,Ling Jiang,Xi Li,Tao Li,Minfeng Huo,Qian Li
标识
DOI:10.1021/acsami.1c18061
摘要
Ferroptosis is a new form of regulated cell death depending on elevated iron (Fe2+) and lipid peroxidation levels. Myocardial ischemia/reperfusion (I/R) injury has been shown to be closely associated with ferroptosis. Therefore, antiferroptosis agents are considered to be a new strategy for managing myocardial I/R injury. Here, we developed polydopamine nanoparticles (PDA NPs) as a new type of ferroptosis inhibitor for cardioprotection. The PDA NPs features intriguing properties in inhibiting Fe2+ accumulation and restoring mitochondrial functions in H9c2 cells. Subsequently, we demonstrated that administration of PDA NPs effectively reduced Fe2+ deposition and lipid peroxidation in a myocardial I/R injury mouse model. In addition, the myocardial I/R injury in mice was alleviated by PDA NPs treatment, as demonstrated by reduced infarct size and improved cardiac functions. The present work indicates the therapeutic effects of PDA NPs against myocardial I/R injury via preventing ferroptosis.
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