MAPK/ERK通路
信号转导
机制(生物学)
发病机制
冲程(发动机)
激酶
生物信息学
细胞信号
神经科学
医学
细胞生物学
生物
癌症研究
免疫学
机械工程
哲学
认识论
工程类
作者
Yangmin Zheng,Ziping Han,Haiping Zhao,Yumin Luo
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2020-10-13
卷期号:19 (4): 248-256
被引量:29
标识
DOI:10.2174/1871527319666200613223018
摘要
Conclusion: Stroke is a complex disease caused by genetic and environmental factors, and its etiological mechanism has not been fully clarified yet, which brings great challenges to its effective prevention and treatment. MAPK signaling pathway regulates gene expression of eukaryotic cells and basic cellular processes such as cell proliferation, differentiation, migration, metabolism and apoptosis, which are considered as therapeutic targets for many diseases. Up to now, mounting evidence has shown that MAPK signaling pathway is involved in the pathogenesis and development of ischemic stroke. However, the upstream kinase and downstream kinase of MAPK signaling pathway are complex and the influencing factors are numerous, the exact role of MAPK signaling pathway in the pathogenesis of ischemic stroke has not been fully elucidated. MAPK signaling molecules in different cell types in the brain respond variously after stroke injury, therefore, the present review article is committed to summarizing the pathological process of different cell types participating in stroke, discussed the mechanism of MAPK participating in stroke. We further elucidated that MAPK signaling pathway molecules can be used as therapeutic targets for stroke, thus promoting the prevention and treatment of stroke.
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